反应详情

To 440 mg of the product of Example 105 dissolved in 10 mL of acetone, 1.0 g of methyl iodide was added. The mixture was refluxed for 10 hours, then the precipitate which formed was collected by suction filtration to give 550 mg of the desired product as yellow leaves melting at 188°-190° C. with decomposition. NMR analysis confirmed that the product had the structural formula: ##STR135##

1. temperatureThe mixture was refluxed for 10 hours
2. customthe precipitate which formed
3. filtrationwas collected by suction filtration