Diethyl Ether → HCID 20074899, compound

Participants

Reaction Steps

Thionyl chloride (7.2 g) was added over 5 min to a stirred suspension of 1-(hydroxymethyl)-2-methyl-1H-imidazole (5.0 g) in a mixture of dichloromethane (50 ml) and DMF (0.5 ml) at 0°, and the mixture was stirred at 0° for 2h. It was then poured into dry ether (500 ml) and left for 1h. The cloudy supernatant was decanted from the insoluble colourless oil which separated. This oil was triturated with acetone (100 ml) with scratching to give a solid which was filtered off and dried to give the title compound (3.6 g), m.p. 122°-124°.

Provenance & Evidence