Sodium borohydride → HCID 15116198, compound

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Reaction Steps

In 20 ml of methanol was dissolved 1 g of the compound of Example 52, and 0.14 g of sodium borohydride was added to the solution and reaction was carried out at room temperature for 12 hours. After removal of the solvent under reduced pressure, 30 ml of chloroform and 30 ml of water were added to the residue and the mixture was stirred. The chloroform layer was separated, dried over sodium sulfate and then condensed and crystallized from chloroform-ethyl acetate to give 0.77 g of the title compound. Melting point: 260° to 265° C. (decomposed).

Provenance & Evidence