HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroacetate → Glycine, N-[3-(trifluoromethyl)phenyl]-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroacetate | HCID 7295 | — |
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | Sodium Acetate Trihydrate | HCID 23665404 | — |
| Product | Glycine, N-[3-(trifluoromethyl)phenyl]-, methyl ester | HCID 251270 | — |
Reaction Steps
3-Trifluoromethylaniline (80.5 g), methyl chloroacetate (44 ml) and sodium acetate trihydrate (114 g) were treated according to the method of Intermediate 1 to give a solid (84 g), a sample of which (ca. 1 g) was purified by FCC eluting with System A (1:1) to give a solid which was recrystallised from System A to give the title compound, m.p. 60°-63°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985427 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-d84c99f7928f4c7ea76bae5facbb8b2f |
| Source note | uspto-grants-1991_01 |