HRID7038

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68021

4-Fluorobenzyl bromide

C7H6BrF

结构：NC(=O)[C@@H]1CCCC[C@@H]1NS(=O)(=O)c1ccc(Cl)cc1

HCID69655699

未命名化合物

PRODUCTS

生成物

结构：NC(=O)[C@@H]1CCCC[C@@H]1N(Cc1ccc(F)cc1)S(=O)(=O)c1ccc(Cl)cc1

HCID69656115

未命名化合物

收率 67%

PROCEDURE

实验过程

The titled compound (178 mg) was prepared in 67% yield from cis-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 1-bromomethyl-4-fluoro-benzene according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.74 (d, 2 H, J=8.0 Hz), 7.60 (d, 2 H, J=8.0 Hz), 7.28 (m, 3 H), 7.05 (m, 2 H), 6.67 (s, 1 H), 4.54 (AB2,2 H,Δv=17,Jab=57 Hz), 3.87 (m, 1 H), 2.76 (m, 1 H), 2.45 (m, 1 H), 1.47 (m, 6 H), 0.97 (m, 1 H); MS m/e 425.02 (M+H)+.