Methyl Isocyanate → HCID 53807400, compound

HRID 703812Notes

Reaction equation

HRID 703812 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([CH2:10][C:11]([O:13][CH3:14])=[O:12])[NH2:9])[CH:5]=[CH:6][CH:7]=1.[CH3:15][N:16]=[C:17]=[O:18]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]([CH2:10][C:11]([O:13][CH3:14])=[O:12])[NH:9][C:17]([NH:16][CH3:15])=[O:18])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 19829917HCID 19829917, compound

Product 1

HCID 53807400HCID 53807400, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Methyl [1-(3-chlorophenyl)hydrazino]acetate (1.78 g) was dissolved in acetonitrile (20 ml) under nitrogen at room temperature. Methyl isocyanate (1.7 ml) was added to the solution which was then heated at 80° for 2 h. The solvent was removed in vacuo to give an oily residue which solidified on standing. This solid was triturated with ether and filtered to give the title compound (2.0 g), m.p. 121°-122°.

Workup

  1. temperaturewas then heated at 80° for 2 h
  2. customThe solvent was removed in vacuo
  3. customto give an oily residue which
  4. customThis solid was triturated with ether
  5. filtrationfiltered

Sources & evidence

ORD record
ord-7d3ad03039b445ac866b55788c61e053
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

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