反应详情

温度

60 °C

In 75 ml of ethanol, 2.8 g of 2-benzylthio-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one prepared in Preparation Example 1 was added and dissolved by warming the mixture to 60° C. To this solution, an aqueous suspension of 35.7 g OXONE ® of in 150 ml of water was added, and the mixture was stirred at 60° C. for 2 hours. After cooling, water was added to dissolve inorganic materials, and the deposited crystals were collected by filtration. The crystals were recrystallized from ethanol, and thus 1.6 g of 2-benzylsulfonyl-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. m.p. 171°-173° C. Yield 52%.

1. additionwas added
2. dissolutiondissolved
3. additionwas added
4. temperatureAfter cooling
5. dissolutionto dissolve inorganic materials
6. filtrationthe deposited crystals were collected by filtration
7. customThe crystals were recrystallized from ethanol