反应详情

Five (5) grams of the thus obtained 2-benzylthio-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one, 5 g of zinc chloride were added to 50 ml of acetic acid. Six (6) grams of iodine monochloride was added to the mixture, and the mixture was stirred at 70°-80° C. for 1 hour. After the reaction was finished, the reaction mixture was cooled and a sodium chloride solution was added. The deposited crystals were collected by filtration, washed with water and isopropyl ether and thus 1.3 g of 2-benzylthio-6-iodo-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. Yield 18%.

1. temperaturethe reaction mixture was cooled
2. filtrationThe deposited crystals were collected by filtration
3. washwashed with water and isopropyl ether