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Water → 1-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Isopropylbenzyl chloride | HCID 74916 | — |
| 反応物 | 4-Benzoylureidopiperidine | HCID 12608582 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea | HCID 12942302 | — |
反応手順
4-Isopropylbenzyl chloride (0.84 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried (1.2 g), m.p. 240°-242° C. as the hydrochloride salt, hemihydrate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04985438 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-2df4f7eb9dd04713b5719322af058a54 |
| 出典メモ | uspto-grants-1991_01 |