HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide → [1-(Naphth-2-ylmethyl)piperid-4-yl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(((1-(2-Naphthalenylmethyl)-4-piperidinyl)amino)carbonyl)benzamide | HCID 72002 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | [1-(Naphth-2-ylmethyl)piperid-4-yl]urea | HCID 13145794 | — |
Reaction Steps
1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (prepared according to Example 1) is hydrolysed by refluxing in 2N sodium hydroxide to give [1-(naphth-2-ylmethyl)piperid-4-yl]urea (m.p. 183°-5° C.). The product is acylated by reaction with 4-methoxybenzoyl chloride to give the title compound, m.p. of HCl, quarterhydrate=193°-193.5° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985438 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-2c76d37b0dc245abbd2bee0e89cad040 |
| Source note | uspto-grants-1991_01 |