Hydrochloric Acid → HCID 15617909, compound

Participants

Reaction Steps

A solution of the compound of Example 94 Part B (5.00 g 15.3 mmole) and bis-(1 3-diphenylphosphino)-propane nickel (II) chloride (0.40 g, 0.74 mmole) in dry ether was stirred at 0°. Phenylmagnesium chloride (2.0M in ether; 9.5 mL 19.0 mmole) was added dropwise and the mixture was stirred at room temperature for 2 hours. The mixture was then poured into 1.0N hydrochloric acid, and the crude product was isolated by extraction with methylene chloride. This was chromatographed to provide the title product (4.26 g, 86%) as a white solid. A small sample recrystallized from hexane melted at 103°-105°.

Provenance & Evidence