Ethanol → HCID 15617943, compound

Participants

Reaction Steps

A mixture of the product of Example 122 Part C (3.79 g, 0.010 mole). potassium cyanide (0.72 g, 0.011 mole), ethanol (15 mL) and water (2 mL) was heated at reflux for 20 hours. The cooled mixture was poured into water and extracted with ethyl acetate. The crude product was chromatographed with 1:1 ether/hexane and recrystallized (cyclohexane/toluene) to provide the title compound (0.73 g, 35%) as a white solid mp 76°-78°.

Provenance & Evidence