HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-(2-Phenylpyrazolo[1,5-a]pyridine-3-yl)methylenerhodanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Rhodanine | HCID 1201546 | — |
| Reactant | 2-Phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde | HCID 15158179 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(2-Phenylpyrazolo[1,5-a]pyridine-3-yl)methylenerhodanine | HCID 54451617 | 86.9% |
Reaction Steps
A mixture of 2-phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde (15.0 g), rhodanine (9.44 g), sodium acetate (16.6 g) and glacial acetic acid (90 ml) was refluxed for hours. Water(200 ml) and ethyl acetate (90 ml) were added to the reaction mixture and the resulting precipitates were collected by filtration to give 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)methylenerhodanine (cis and trans mixture) (19.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985444 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-93c75b3ca8d1406f8c3cd9eb6f37d826 |
| Source note | uspto-grants-1991_01 |