反应详情

温度

200 °C

A mixture of 3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acrylaldehyde (cis and trans mixture) (1.15 g) and 1-carbamoylmethylpyridinium chloride (0.80 g), 50% aqueous dimethylamine (0.44 g) and methanol (10 ml) was refluxed for 3 hours. The reaction mixture was evaporated in vacuo and the residue was heated for 10 minutes at 200° C. The resulting mixture was chromatographed on silica gel (80 g) with a mixture of chloroform and methanol (100:1). The fractions containing ton silica gel (80 g) with a mixture of chloroform and methanol (100:1). The fractions containing the object compound were combined and evaporated in vacuo and recrystallized from ethanol to give 3-(2-oxo-1,2-dihydropyridin-4-yl)-2-phenylpyrazolo[1,5-a]pyridine (0.33 g).

1. temperaturewas refluxed for 3 hours
2. customThe reaction mixture was evaporated in vacuo
3. customThe resulting mixture was chromatographed on silica gel (80 g) with a mixture of chloroform and methanol (100:1)
4. additionThe fractions containing ton silica gel (80 g)
5. additionwith a mixture of chloroform and methanol (100:1)
6. additionThe fractions containing the object compound
7. customevaporated in vacuo
8. customrecrystallized from ethanol