Sodium Hydroxide → HCID 178525590, compound

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Reaction Steps

A mixture of 3-[1-(2-methoxycarbonylethyl)-5-hydroxypyrazol-3-yl]-2-phenylpyrazolo[1,5-a]pyridine (0.50 g), 1N sodium hydroxide aqueous solution (3 ml) and ethanol (5 ml) was heated under reflux for 2.5 hours. Ethanol was evaporated in vacuo. The residue was acidified with 5% hydrochloric acid and extracted with chloroform (25 ml×2). Combined extract was washed with a saturated aqueous solution of sodium chloride (25 ml), dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel using a mixture of chloroform and methanol (30:1) as an eluent and recrystallized from ethanol to give crystal of 3-[1-(2-carboxyethyl)-5-hydroxypyrazol-3-yl]-2-phenylpyrazolo[1,5-a]pyridine (141 mg).

Provenance & Evidence