HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 703993Generated: October 26, 2026
Pyridine → 3-[3-(2-Hydroxy-3,3,3-trichloropropyl)pyridazin-4-yl]-2-phenylpyrazolo[1,5-a]pyridine
https://huagongshe.com/reaction/703993
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 3-(3-Methylpyridazin-4-yl)-2-phenylpyrazolo[1,5-a]pyridine | HCID 15158108 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[3-(2-Hydroxy-3,3,3-trichloropropyl)pyridazin-4-yl]-2-phenylpyrazolo[1,5-a]pyridine | HCID 15158151 | 42.9% |
Reaction Steps
A mixture of 3-(3-methylpyridazin-4-yl)-2-phenylpyrazolo[1,5-a]pyridine (0.40 g), chloral hydrate (0.70 g) and pyridine (4 ml) was stirred for 20 hours at 90-100° C. After cooling, to the reaction mixture was added methylene chloride (4 ml) and water (4 ml) at room temperature, and stirred for 3 hours. The precipitates were collected by filtration to give 3-[3-(2-hydroxy-3,3,3-trichloropropyl)pyridazin-4-yl]-2-phenylpyrazolo[1,5-a]pyridine (0.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04985444 |
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| Source dataset | uspto-grants-1991_01 |
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| ORD ID | ord-b893f67f904a4481b3e98d8040a6574d |
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| Source note | uspto-grants-1991_01 |
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