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2-Morpholinoethylamine → N-[2-(4-Morpholinyl)ethyl]-4-methylpyridazino[4,5-b]indolizin-1-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Morpholinoethylamine | HCID 408285 | — |
| 反応物 | 1-Chloro-4-methylpyridazino[4,5-b]indolizine | HCID 15713312 | — |
| 生成物 | N-[2-(4-Morpholinyl)ethyl]-4-methylpyridazino[4,5-b]indolizin-1-amine | HCID 15713315 | — |
反応手順
Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 27 equivalents of 4-(2-aminoethyl)morpholine gave the title compound as the free base which was converted to the dihydrochloride salt (MeOH/ethereal HCl/diethyl ether), mp 310° C. (dec).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04985560 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-ed30324bb00c4b04b2db11ae77c59b13 |
| 出典メモ | uspto-grants-1991_01 |