HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminomethyl-1-ethylpyrrolidine → N-[(1-Ethyl-2-pyrrolidinyl)methyl]-4-methylpyridazino[4,5-b]-indolizin-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| Reactant | 1-Chloro-4-methylpyridazino[4,5-b]indolizine | HCID 15713312 | — |
| Product | N-[(1-Ethyl-2-pyrrolidinyl)methyl]-4-methylpyridazino[4,5-b]-indolizin-1-amine | HCID 15713317 | — |
Reaction Steps
Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 27 equivalents of 2-(aminomethyl)-1-ethylpyrrolidine gave the title compound as the free base which was converted to the dihydrochloride salt, mp. 128° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985560 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-cb8667e7c7d846d7aecad49f86831872 |
| Source note | uspto-grants-1991_01 |