Piperidine-1-propylamine → HCID 15713319, compound

HRID 704078Notes

Reaction equation

HRID 704078 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[C:9]3[N:14]([C:6]=2[C:5]([CH3:15])=[N:4][N:3]=1)[CH:13]=[CH:12][CH:11]=[CH:10]3.[NH2:16][CH2:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH3:15][C:5]1[N:4]=[N:3][C:2]([NH:16][CH2:17][CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[C:7]2[C:6]=1[N:14]1[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]1)=[CH:8]2

Participants

3

Reactant 2

HCID 19049Piperidine-1-propylamineHCID 157133121-Chloro-4-methylpyridazino[4,5-b]indolizine

Product 1

HCID 15713319HCID 15713319, compound

Procedure

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of 1-(3-aminopropyl)piperidine at 130° C. gave the title compound as the free base (oil, 83%) after HPLC purification. Trituration with hexane gave a yellow solid (50%), mp 130°-134° C. The free base was then converted to the dihydrochloride salt (MeOH/ethereal HCl/diethyl ether), mp. 302°-303° C.

Sources & evidence

ORD record
ord-a84022cdbf1c41aa84ff0e60701b1e39
Source dataset
uspto-grants-1991_01
Patent number
US04985560

Reaction notes

Loading…