反应详情

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of 1-(3-aminopropyl)piperidine at 130° C. gave the title compound as the free base (oil, 83%) after HPLC purification. Trituration with hexane gave a yellow solid (50%), mp 130°-134° C. The free base was then converted to the dihydrochloride salt (MeOH/ethereal HCl/diethyl ether), mp. 302°-303° C.