Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Piperazinecarboxaldehyde → 4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| 반응물 | 1-Chloro-4-methylpyridazino[4,5-b]indolizine | HCID 15713312 | — |
| 생성물 | 4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde | HCID 15713337 | — |
반응 단계
Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of piperazinecarboxaldehyde at 150° C. gave the title compound as the free base, which was purified by flash chromatography (silica gel, 1 to 20% methanol:ethyl acetate) and converted to the dihydrochloride salt (MeOH/etheral HCl/diethyl ether), mp 325° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04985560 |
| 출처 데이터셋 | uspto-grants-1991_01 |
| ORD ID | ord-8d64ab1e5902489abae5d19b42e1f524 |
| 출처 메모 | uspto-grants-1991_01 |