反应详情

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 3 equivalents of 3-(3-azabicyclo[3.2.2]non-3-yl)propylamine at 150° C. overnight gave the title compound as the free base which was purified by chromatography (silica gel, 1:4 methanol:methylene chloride containing ammonium hydroxide) and converted to the dihydrochloride salt (ethanol/etheral HCl), mp 343° C. dec.