HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86744519, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-(3-Aminopropyl)-2-pyrrolidinone | HCID 82111 | — |
| Reactant | 1-Chloro-4-methylpyridazino[4,5-b]indolizine | HCID 15713312 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86744519 | HCID 86744519 | — |
Reaction Steps
Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine, five equivalents of 1-(3-aminopropyl)pyrrolidinone, and one quivalent of ammonium chloride at reflux under nitrogen for 3 hours gave the title compound as the free base after flash column chromatography (silica gel, methanol:ethyl acetate). This was converted to the hydrochloride salt, mp 257°-258° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985560 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-1f9480bd78cc4c50a27ab44f1ac48ed4 |
| Source note | uspto-grants-1991_01 |