Ammonium Chloride → HCID 67920597, compound

Participants

Reaction Steps

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine, eight equivalents of 3-(1H-imidazol-1-yl)propylamine and one equivalent of ammonium chloride under reflux in a nitrogen atmosphere for 1 hour and at room temperature for 48 hours gave the title compound as the free base after removal of excess amine in vacuo and purification by flash chromatography (silica gel, 10 to 40% methanol in ethyl acetate). The free base was converted to the dihydrochloride salt (methanol/ethereal HCl/diethyl ether), mp 162°-163° C.

Provenance & Evidence