HRID7041

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID142785

4-(Trifluoromethoxy)benzyl bromide

C8H6BrF3O

结构：NC(=O)[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(Cl)cc1

HCID69656245

未命名化合物

PRODUCTS

生成物

结构：NC(=O)[C@@H]1CCCC[C@H]1N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(Cl)cc1

HCID11225600

未命名化合物

收率 20%

PROCEDURE

实验过程

The titled compound was prepared in 20% yield from trans-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 1-bromomethyl-4-trifluoromethoxy-benzene according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.63 (d, 2 H, J=8.0 Hz), 7.43 (m, 4 H), 7.37 (s br, 1 H), 7.18 (d, 2 H, J=8.0 Hz), 6.81 (s br, 1 H), 4.36 (AB2, 2 H,Δv=12,Jab=72 Hz), 4.01 (s br, 1 H), 1.83 (m, 1 H), 1.30 (m, 8 H); MS m/e 490.97 (M+H)+.