HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetophenone, 2',4'-dichloro-5'-fluoro- → 2,4-Dichloro-5-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetophenone, 2',4'-dichloro-5'-fluoro- | HCID 727250 | — |
| Reactant | HCID 178527019 | HCID 178527019 | — |
| Product | 2,4-Dichloro-5-fluorobenzoic acid | HCID 688138 | — |
Reaction Steps
Namely, 2,4-dichloro-5-fluoroacetophenone is subjected to a haloform reaction in a 12% sodium hypophosphite aqueous solution to obtain 2,4-dichloro-5-fluorobenzoic acid. Then, this benzoic acid is reacted with an alcohol or with a phenol in the presence of an acid catalyst to obtain the above-mentioned fluorine-containing benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985588 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-aecb18ae08a242f6b4dacf28a42ba04f |
| Source note | uspto-grants-1991_01 |