3-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamide → Calcium

HRID 704127Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[C:6]([NH:10][CH2:11][C:12]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2].O[CH2:28][S:29]([O-:32])(=[O:31])=[O:30].[Ca+2:33].O[CH2:35][S:36]([O-:39])(=[O:38])=[O:37]>>[Ca:33].[OH2:3].[C:1]([C:4]1[CH:5]=[C:6]([N:10]([CH2:28][S:29]([OH:32])(=[O:31])=[O:30])[CH2:11][C:12]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2].[C:1]([C:4]1[CH:5]=[C:6]([N:10]([CH2:35][S:36]([OH:39])(=[O:38])=[O:37])[CH2:11][C:12](=[O:13])[NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)[CH:7]=[CH:8][CH:9]=1)(=[O:3])[NH2:2]

Participants

Reactant 2

HCID 1566513-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamide

HCID 88512835Calcium hydroxymethanesulfonate

Product 2

HCID 5460341Calcium

HCID 131716758N-(3-carbamoylphenyl)-N-(2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)aminomethanesulfonate hemihydrate

Procedure

2-(3-Carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide (hereinafter referred to Compound A) was reacted with calcium hydroxymethanesulfonate in the same manner as described in Example 16 to give calcium bis(N-(3-carbamoylphenyl)-N-(2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)aminomethanesulfonate hemihydrate as colorless crystals with m.p. 265° to 267° C. (decomposition).

Sources & evidence

ORD record: ord-4ae8dfe5af5742eb9f8c8f7d953c24ee
Source dataset: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04985595

Reaction notes

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