4-Chloro-2-fluorobenzene-1-sulfonyl chloride → 4-chloro-N-[5-chloro-2-(methylthio)phenyl]-2-fluorobenzenesulfonamide

HRID 70415Notes

Reaction equation

HRID 70415 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH3:10])=[C:6]([NH2:8])[CH:7]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[C:14]([F:22])[CH:13]=1>>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:8][C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[S:9][CH3:10])(=[O:19])=[O:20])=[C:14]([F:22])[CH:13]=1

Participants

3

Reactant 2

HCID 27788604-Chloro-2-fluorobenzene-1-sulfonyl chlorideHCID 27945775-Chloro-2-(methylthio)aniline

Product 1

HCID 573789964-chloro-N-[5-chloro-2-(methylthio)phenyl]-2-fluorobenzenesulfonamideYield 66.1%

Procedure

Following General Procedure B, the title compound (380 mg, 66%) was prepared from 5-chloro-2-methylsulfanyl-phenylamine (273 mg, 1.57 mmol) and 4-chloro-2-fluoro-benzenesulfonyl chloride (360 mg, 1.57 mmol).

Sources & evidence

ORD record
ord-4bb618e9a47c48f6b277308e0b2ae502
Source dataset
uspto-grants-2014_09
Patent number
US08822530B2

Reaction notes

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