Tetrahydrofuran → HCID 14496321, compound

Participants

Reaction Steps

120.9 g (0.4 mol) of 4-benzyloxy-4'-acetylbiphenyl, 400 ml of tetrahydrofuran and 100 ml of methanol were supplied into a four-necked flask provided with a stirrer and a thermometer. Then 15.14 g (0.4 mol) of sodium borohydride was added at 15°-25° C. over a period of 2 hours. The mixture was kept at the same temperature for 5 hours, then poured into ice-water and extracted twice with 500 ml of chloroform. The organic layer was concentrated under reduced pressure to obtain 117.4 g (96.5% yield) or 4-benzyloxy-4'-(1-hydroxyethyl)-biphenyl (VI-12).

Provenance & Evidence