Tetrahydrofuran → HCID 14496321, compound

Participants

Reaction Steps

12.09 g (0.04 mol) of 4'-acetyl-4-benzyloxybiphenyl (VII-23), 40 ml of tetrahydrofuran and 10 ml of methanol were supplied into a four-necked flask provided with a stirrer and a thermometer. Then 1.51 g (0.4 mol) of sodium boron hydride was added at 15°-25° C. over a period of 2 hours. The mixture was kept at the same temperature for 5 hours, then poured into ice-water and extracted with 50 ml of chloroform. The organic layer was concentrated under reduced pressure to give 11.0 g (95% yield) of 4-benzyloxy-4'-(1-hydroxyethyl)biphenyl (VI-23).

Provenance & Evidence