2-Amino-4-chlorobenzenethiol → N-{5-chloro-2-[(1H-imidazol-2-ylmethyl)thio]phenyl}-1-benzofuran-2-sulfonamide

HRID 70419Notes

Reaction equation

HRID 70419 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[SH:9].Cl[CH2:11][C:12]1[NH:13][CH:14]=[CH:15][N:16]=1.[O:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[C:18]1[S:26](Cl)(=[O:28])=[O:27]>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][CH2:11][C:12]2[NH:13][CH:14]=[CH:15][N:16]=2)=[C:2]([NH:1][S:26]([C:18]2[O:17][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH:19]=2)(=[O:27])=[O:28])[CH:7]=1

Participants

4

Reactant 3

HCID 120002-Amino-4-chlorobenzenethiolHCID 4257632-(chloromethyl)-1H-imidazoleHCID 27951721-Benzofuran-2-sulfonyl chloride

Product 1

HCID 57377452N-{5-chloro-2-[(1H-imidazol-2-ylmethyl)thio]phenyl}-1-benzofuran-2-sulfonamide

Procedure

Following General Procedure A, B, the title compound was prepared from 2-Amino-4-chloro-benzenethiol, 2-chloromethyl-1H-imidazole and 1-benzofuran-2-sulfonyl chloride.

Sources & evidence

ORD record
ord-dbc05e4656ea4c7888214420032c162b
Source dataset
uspto-grants-2014_09
Patent number
US08822530B2

Reaction notes

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