Triethylamine → 2-(2-Cyano-10-phenothiazinyl)propyl mesylate

Participants

Reaction Steps

Triethylamine (16.2 cc) is added with stirring to a solution, cooled to a temperature in the region of 5° C., of 10-(1-hydroxy-2-propyl)phenothiazinecarbonitrile, D series (20 g) in methylene chloride (200 cc), a solution of methanesulphonyl chloride (8.9 cc) in methylene chloride (89 cc) is then introduced dropwise during 25 minutes, and stirring is continued for 50 minutes at a temperature in the region of 10° C. The reaction mixture is washed successively with distilled water (2×100 cc) and with saturated aqueous sodium chloride solution (100 cc), dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. 2-(2-Cyano-10-phenothiazinyl)-1-propyl methanesulphonate, D series (25.8 g) is thereby obtained in the form of an orange gum, which is used without further purification for the next stage of the synthesis.

Provenance & Evidence