Hydrochloric Acid → HCID 86744528, compound

Participants

Reaction Conditions

Reaction Steps

A 2.2N ethereal solution (0.41 cc) of hydrochloric acid is added to a solution of 10-{1-[(2S)-2-hydroxymethyl-1-pyrrolidinyl]-2-propyl}-N-(3-methylbutyl)-2-phenothiazinecarbothioamide, L series (0.42 g) in ethyl ether (40 cc). A gummy precipitate is deposited on the walls of the flask. The mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. The suspension is stirred for 12 hours at 25° C. in ethyl ether (50 cc). The precipitate is separated by filtration, washed with ethyl ether (2×10 cc) and dried at 40° C. under reduced pressure (5 mm Hg; 0.068 kPa) to give 10-{1-[(2S)-2-hydroxymethyl-1-pyrrolidinyl]-2-propyl}-N-(3-methylbutyl)-2-phenothiazinecarbothioamide hydrochloride, L series (0.39 g), m.p. 131° C.

Provenance & Evidence