Hydrochloric Acid → HCID 67922590, compound

Participants

Reaction Steps

A 2.2N ethereal solution (2.02 cc) of hydrochloric acid is added to a solution of 10-{1-[(2R)-2-acetoxymethyl-1-pyrrolidinyl]-2-propyl}-N-(3-methylbutyl)- 2-phenothiazinecarboxamide, L series (2.40 g) in acetonitrile (14 cc). The solution obtained is introduced dropwise into ethyl ether (400 cc), briskly stirred; a precipitate develops and the suspension is stirred for 12 hours at 25° C. The precipitate is filtered off on sintered glass, washed with ethyl ether (3×20 cc) and dried at 40° C. under reduced pressure (5 mm Hg; 0.068 kPa) to give 10-{1-[(2R)-2-acetoxymethyl-1-pyrrolidinyl]-2-propyl}-N-(3-methylbutyl)-2-phenothiazinecarboxamide hydrochloride, L series (2.17 g), m.p. 140° C.

Provenance & Evidence