Hydrochloric Acid → HCID 67922555, compound

Participants

Reaction Conditions

Reaction Steps

2.4N ethereal hydrochloric acid (2.9 cc) is added to a solution of 2-(3a,4,5,6,7,7a-hexahydro-1H-benzimidazol-2-yl)-10-{1-[(2R)-2-hydroxymethyl-1-pyrrolidinyl]-2-propyl}phenothiazine, L series (1.8 g) in absolute ethanol (14 cc). The solution thereby obtained is added dropwise to ethyl ether (500 cc) with brisk stirring. When the addition is complete, the suspension is stirred for 15 minutes at 25° C. and the mixture is filtered and washed with ethyl ether (3×25 cc) and the cake is then dried at 40° C. under reduced pressure (10 mm Hg; 1.3 kPa). 2-(3a,4,5,6,7,7a-Hexahydro-1H-benzimidazol-2-yl)-10-{1-[(2R)-2-hydroxymethyl-1-pyrrolidinyl]-2-propyl}phenothiazine dihydrochloride, L series (1.48 g) is thereby obtained in the form of an amorphous pale yellow solid, m.p. 240° C.

Provenance & Evidence