Prolinol, (R)- → HCID 54020022, compound

HRID 704232Notes

Reaction equation

HRID 704232 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][OH:7].CS(O[CH2:13][CH:14]([N:16]1[C:29]2[CH:28]=[C:27]([C:30]#[N:31])[CH:26]=[CH:25][C:24]=2[S:23][C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH3:15])(=O)=O>C(O)C>[OH:7][CH2:6][C@H:2]1[CH2:3][CH2:4][CH2:5][N:1]1[CH2:15][CH:14]([N:16]1[C:29]2[CH:28]=[C:27]([C:30]#[N:31])[CH:26]=[CH:25][C:24]=2[S:23][C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH3:13]

Participants

4

Reactant 2

HCID 2724541Prolinol, (R)-HCID 145021392-(2-Cyano-10-phenothiazinyl)propyl mesylate

Product 1

HCID 54020022HCID 54020022, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(R)-(-)-2-Pyrrolidinylmethanol (50 g) is added to a suspension of (2RS)-2-(2-cyano-10-phenothiazinyl)propyl methanesulphonate (89.1 g) in absolute ethanol (2000 cc). The mixture is brought to reflux for 23 hours. After cooling, the mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa). The residue is diluted with ethyl acetate (350 cc) and filtered, and the filtrate is washed with distilled water (150 cc) and saturated sodium chloride solution (2×100 cc). After settling has taken place, the organic phase is extracted with hydrochloric acid (350 cc) in 3N solution. The acidic aqueous extracts are extracted with ethyl acetate (200 cc) and then alkalinized with concentrated sodium hydroxide and re-extracted with ethyl acetate (3×200 cc). The organic phase is washed with distilled water (2×200 cc) and then dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 50° C. to give a residue which is purified by chromatography on a column (height: 46 cm; diameter: 8.5 cm) of silica gel (0.2-0.06 mm), eluting with mixtures of cyclohexane and ethyl acetate in proportions (by volume) of 80:20 (12 liters) and 70:30 (30 liters), collecting 250-cc fractions. The first 12 liters are discarded and fractions 61 to 118 are combined and evaporated under reduced pressure (30 mm Hg; 4 kPa) at 40° C. to give 10-{1-[(2R)-2-hydroxymethyl-1-pyrrolidinyl]-2-propyl}-2-phenothiazinecarbonitrile, L series (11.0 g) in the form of a yellow product of meringue-like consistency.

Workup

  1. temperatureto reflux for 23 hours
  2. temperatureAfter cooling
  3. concentrationthe mixture is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa)
  4. additionThe residue is diluted with ethyl acetate (350 cc)
  5. filtrationfiltered
  6. washthe filtrate is washed with distilled water (150 cc) and saturated sodium chloride solution (2×100 cc)
  7. extractionthe organic phase is extracted with hydrochloric acid (350 cc) in 3N solution
  8. extractionThe acidic aqueous extracts are extracted with ethyl acetate (200 cc)
  9. extractionre-extracted with ethyl acetate (3×200 cc)
  10. washThe organic phase is washed with distilled water (2×200 cc)
  11. dry with materialdried over magnesium sulphate
  12. filtrationfiltered
  13. concentrationconcentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 50° C.
  14. customto give a residue which
  15. customis purified by chromatography on a column (height: 46 cm; diameter: 8.5 cm) of silica gel (0.2-0.06 mm)
  16. washeluting with mixtures of cyclohexane and ethyl acetate in proportions (by volume) of 80:20 (12 liters) and 70:30 (30 liters)
  17. customcollecting 250-cc fractions
  18. customevaporated under reduced pressure (30 mm Hg; 4 kPa) at 40° C.

Sources & evidence

ORD record
ord-31b8ce3526604101bb937672f0b9ef37
Source dataset
uspto-grants-1991_01
Patent number
US04985419

Reaction notes

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