反应详情

温度

5 °C

Thionyl chloride (0.5 cc) is introduced during 5 minutes and with stirring into a suspension of 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxylic acid hydrochloride (1 g) in methylene chloride (30 cc) while the temperature is maintained in the vicinity of 5° C. Stirring is continued for 40 minutes while heating to a temperature in the region of 30° C., and the yellow solution obtained is concentrated to dryness under reduced pressure (30 mm Hg; 4kPa) at 40° C. The residue is dissolved in methylene chloride (30 cc) and 3-methyl-2butenylamine (0.73 g) and triethylamine (0.84 cc) are added. Stirring is maintained for 30 minutes at 20° C. The reaction mixture is diluted with ethyl acetate (100 cc), washed successively with N aqueous sodium hydroxide solution (50 cc) and then with saturated aqueous sodium chloride solution (2×50 cc), dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C. The oily orange residue (0.9 g) is dissolved in a mixture (30:70 by volume) (35 cc) of ethyl acetate and isopropyl ether, and a 0.3N solution (5.5 cc) of hydrochloric acid in isopropyl ether is added with stirring at 6° C. After one hour's stirring at 6° C., the solid formed is filtered off, washed with isopropyl ether (5 cc) and dried under reduced pressure (5 mm Hg; 0.67 kPa) at 40° C. to give N-(3-methyl-2-butenyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride (0.52 g) in the form of a cream-coloured solid, m.p. about 150° C.

1. temperaturewhile heating to a temperature in the region of 30° C.
2. customthe yellow solution obtained
3. concentrationis concentrated to dryness under reduced pressure (30 mm Hg; 4kPa) at 40° C
4. dissolutionThe residue is dissolved in methylene chloride (30 cc)
5. addition3-methyl-2butenylamine (0.73 g) and triethylamine (0.84 cc) are added
6. stirringStirring
7. temperatureis maintained for 30 minutes at 20° C
8. additionThe reaction mixture is diluted with ethyl acetate (100 cc)
9. washwashed successively with N aqueous sodium hydroxide solution (50 cc)
10. dry with materialwith saturated aqueous sodium chloride solution (2×50 cc), dried over magnesium sulphate
11. filtrationfiltered
12. concentrationconcentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C
13. dissolutionThe oily orange residue (0.9 g) is dissolved in a mixture (30:70 by volume) (35 cc) of ethyl acetate and isopropyl ether
14. additiona 0.3N solution (5.5 cc) of hydrochloric acid in isopropyl ether is added
15. stirringwith stirring at 6° C
16. stirringAfter one hour's stirring at 6° C.
17. customthe solid formed
18. filtrationis filtered off
19. washwashed with isopropyl ether (5 cc)
20. customdried under reduced pressure (5 mm Hg; 0.67 kPa) at 40° C.