HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Nitrophenyl)methanamine → N-(2-nitrobenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Nitrophenyl)methanamine | HCID 423893 | — |
| Reactant | 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride | HCID 20074886 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-nitrobenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide | HCID 20074883 | 36.9% |
Reaction Steps
By working in a manner similar to that described in Example 103, but starting with 10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonyl chloride hydrochloride (2.5 g) in dichloromethane (50 cc) and with 2-nitrobenzylamine (2.1 g), N-(2-nitrobenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.1 g) is obtained, after recrystallization in isopropyl ether, in the form of yellow crystals, m.p. 95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04985419 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-6cd4e6c7cb5a4544b493d586f7f756f4 |
| Source note | uspto-grants-1991_01 |