反应详情

温度

25 °C

A 3.5N acetone solution (2.24 cc) of hydrochloric acid is added dropwise to an acetone solution (11 cc) of 10-[(2RS)-1-diethylamino-2-propyl]-N-[(2RS)-2-methylbutyl]-2-phenothiazinecarboxamidine (1.11 g). The mixture is stirred for 3 hours at 25° C. and then concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 50° C. The residue is taken up in ethyl ether (50 cc) and the suspension is kept stirred for 3 hours at 25° C. The solid is filtered off on sintered glass, washed with ethyl ether (2×5 cc) and dried for 12 hours under reduced pressure (5 mm Hg; 0.7 kPa) to give 10-[(2RS)-1-diethylamino-2-propyl]-N-[(2RS)-2-methylbutyl]-2-phenothiazinecarboxamidine dihydrochloride (1.07 g), m.p. 212°-214° C.

1. concentrationconcentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 50° C
2. stirringthe suspension is kept stirred for 3 hours at 25° C
3. filtrationThe solid is filtered off on sintered glass
4. washwashed with ethyl ether (2×5 cc)
5. customdried for 12 hours under reduced pressure (5 mm Hg; 0.7 kPa)