Pyridine → HCID 131716760, compound

Participants

Reaction Steps

To a suspension of phosphorus pentachloride (366 mg) in methylene chloride (6 ml) was added pyridine (0.142 ml) at -30° C. After the mixture was stirred for 30 minutes at the same temperature, p-nitrobenzyl 7-(2-phenylacetamido)-3-vinylthio-3-cephem-4-carboxylate (300 mg) was added thereto at -30° C. The mixture was stirred for 1 hour under the ice-cooling to the mixture was added methanol (0.38 ml) at -30° C., and the mixture was stirred for 2 hours at -15°~-20° C. Water (0.4 ml) was added thereto under ice-cooling. Diisopropyl ether (5 ml) was added to the mixture to give a precipitate. The precipitate was collected, washed with water and diisopropyl ether successively and dried over phosphorus pentoxide to give p-nitrobenzyl 7-amino-3-vinylthio-3-cephem-4-carboxylate hydrochloride (181 mg).

Provenance & Evidence