1-Benzofuran-2-sulfonyl chloride → HCID 71714811, compound

HRID 70431Notes

Reaction equation

HRID 70431 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[S:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7](=[O:19])[CH2:6][CH2:5]2.[O:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[CH:22]=[C:21]1[S:29](Cl)(=[O:31])=[O:30]>N1C=CC=CC=1>[CH2:12]([S:11][C:10]1[CH:9]=[C:8]2[C:4]([CH2:5][CH2:6][C:7]2=[O:19])=[CH:3][C:2]=1[NH:1][S:29]([C:21]1[O:20][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[CH:22]=1)(=[O:30])=[O:31])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 27951721-Benzofuran-2-sulfonyl chlorideHCID 86690992HCID 86690992, compound

Product 1

HCID 71714811HCID 71714811, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following General Procedure B, the title compound (752 mg, 47%) was prepared from 5-Amino-6-(benzylthio)-2,3-dihydro-1H-inden-1-one (463 mg, 1.72 mmol) and benzofuran-2-sulfonyl chloride (371 mg, 1.72 mmol) in pyridine (3 ml).

Sources & evidence

ORD record
ord-9462767c929a49729901a4c49f8570c9
Source dataset
uspto-grants-2014_09
Patent number
US08822530B2

Reaction notes

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