HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-[1-Hydroxy-2-(4-(4-methyl-2-thiazolyl)-piperazino)-ethyl]salicylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(4-Methyl-1,3-thiazol-2-yl)piperazine | HCID 14479872 | — |
| Reactant | 5-(2-Bromo-1-hydroxyethyl)-salicylamide | HCID 14479873 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-[1-Hydroxy-2-(4-(4-methyl-2-thiazolyl)-piperazino)-ethyl]salicylamide | HCID 14479874 | — |
Reaction Steps
18.9 g of 1-(4-methyl-2-thiazolyl)-piperazine and 26 g of 5-(2-bromo-1-hydroxyethyl)-salicylamide (obtainable by acylation of salicyamide with bromoacetyl bromide/AlCl3 to give 5-bromoacetyl-salicylamide and subsequent reaction with NaBH4) are dissolved in 400 ml of ether, 15 ml of triethylamine are added, the mixture is boiled for 2 h and subjected to the usual working-up, and 5-[1-hydroxy-2-(4-(4-methyl-2-thiazolyl)-piperazino)-ethyl]salicylamide ("A"), m.p. 182°, is obtained. Dihydrochloride m.p. 244°-245°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04987133 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-36b26afb54da46fb8c339c8f6342a94e |
| Source note | uspto-grants-1991_01 |