p-Toluenesulfonic acid → HCID 14800481, compound

Participants

Reaction Steps

A mixture of 2-acetylamino-N-[4-(4-trifluoromethylsulfonyloxyphenoxy)benzyl]aniline (500 mg), p-toluenesulfonic acid (50 mg) and toluene (50 ml) was heated under reflux while removing the by-produced water therefrom through a Dean-Stark trap. After the by-production of water ceased, the reaction mixture was cooled to room temperature, washed with a saturated sodium carbonate solution and water in order and distilled under reduced pressure to eliminate toluene. The residue was purified by silica gel column chromatography to give 2-methyl-1-[4-(4-trifluoromethylsulfonyloxyphenoxy)benzyl]benzimidazole (433 mg) as a colorless oil. nD25.0 1.5670.

Provenance & Evidence