Sodium Hydroxide → HCID 14800483, compound

Participants

Reaction Steps

A mixture of 2-fluoro-6-[4-(4-methylsulfonyloxyphenoxy)benzylamino]aniline (300 mg) and ethyl ortho-acetate (181 mg) was heated at 150° to 160° C. for 24 hours while stirring. The reaction mixture was cooled to room temperature, toluene (100 ml) and a 5% sodium hydroxide solution (50 ml) were added thereto, and the resultant mixture was stirred for 10 minutes The toluene layer was separated, washed with water, dried over anhydrous sodium sulfate and distilled under reduced pressure to eliminate toluene. The residue was purified by silica gel column chromatography to give 4-fluoro-1-[4-(4-methylsulfonyloxyphenoxy)benzyl]-2-methylbenzimidazole (243 mg) as white crystals m.p., 48°-56° C.

Provenance & Evidence