Water → HCID 14280419, compound

HRID 704332Notes

Reaction equation

HRID 704332 reaction equation
[CH3:1][C:2](=[C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[NH:7][C:8](=[O:13])[C:9]([F:12])([F:11])[F:10])[C:3](O)=[O:4].O>C(OC(=O)C)(=O)C>[CH3:1][C:2]1[C:3](=[O:4])[O:13][C:8]([C:9]([F:12])([F:11])[F:10])=[N:7][C:6]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 962WaterHCID 53712489HCID 53712489, compound

Product 1

HCID 14280419HCID 14280419, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent2×

Procedure

39.3 g of the product of Step B were refluxed in 80 ml of acetic anhydride and maintained at this temperature for 30 minutes and then allowed to cool. The acetic anhydride was expelled under reduced pressure and iced water was added to the residue. The precipitate obtained was separated, washed abundantly with water and then dissolved in ether. The organic solution was dried and concentrated to dryness under reduced pressure to obtain 34 g of the expected product melting at 70° C.

Workup

  1. temperaturemaintained at this temperature for 30 minutes
  2. temperatureto cool
  3. additionwas added to the residue
  4. customThe precipitate obtained
  5. customwas separated
  6. washwashed abundantly with water
  7. dissolutiondissolved in ether
  8. customThe organic solution was dried
  9. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-c36f570093104913b4ecbfd97f74677f
Source dataset
uspto-grants-1991_01
Patent number
US04987140

Reaction notes

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