HCID 86743919, compound → HCID 54273364, compound

HRID 704339Notes

Reaction equation

HRID 704339 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][C:6](=[C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)C(O)=O)[CH3:7])=[O:4]>[Cr]([O-])([O-])=O.[Cu+2].N1C2C(=CC=CC=2)C=CC=1>[CH3:7][C:6]([NH:5][C:3](=[O:4])[C:2]([F:1])([F:18])[F:19])=[CH:8][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 86743919HCID 86743919, compound

Product 1

HCID 54273364HCID 54273364, compoundYield 99.8%

Reagents, catalysts & solvents 2

HCID 178505374HCID 178505374, compoundCatalystHCID 7047QuinolineSolvent

Procedure

To 11.7 g of the product of Step B, 60 ml of quinoline and 600 mg of copper chromite were added and the mixture with vigorous stirring was plunged into a metallic bath heated to 230° to 240° C. for 10 minutes. The mixture was cooled and filtered, and the filtrate was taken up in ether, washed with normal hydrochloric acid and then with water, dried and concentrated under reduced pressure to obtain 9.8 g of the expected product.

Workup

  1. customwas plunged into a metallic bath
  2. temperatureheated to 230° to 240° C. for 10 minutes
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. washwashed with normal hydrochloric acid
  6. dry with materialwith water, dried
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-926031f4e13e49ba94e6f146b7f5eec9
Source dataset
uspto-grants-1991_01
Patent number
US04987140

Reaction notes

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