反应详情

A mixture of methyl 4-(((4-chloro-2-(4-chloro-3-(trifluoromethyl)phenylsulfonamido)phenyl)thio)methyl)benzoate (635 mg, 1.155 mmol), NaOH (5M, 2 ml) in MeOH (10 ml) was stirred at room temperature overnight. The solvent was removed and the residue was diluted with water, acidified with 10% HCl. The mixture was extracted with EtOAc (2×20 ml). The combined organic layer was washed with brine and concentrated under vacuum. The desire product was purified by MPLC (50% to 100% EtOAc/Hexane).

1. customThe solvent was removed
2. additionthe residue was diluted with water
3. extractionThe mixture was extracted with EtOAc (2×20 ml)
4. washThe combined organic layer was washed with brine
5. concentrationconcentrated under vacuum
6. customThe desire product was purified by MPLC (50% to 100% EtOAc/Hexane)