反应详情

To a solution of 3 g ethyl 6-[p-[5-(1-imidazolyl)pentyloxy]phenoxy]-2,2-dimethylhexanoate in 15 ml methanol, was added a solution of 580 mg sodium hydroxide in 6 ml water, and the mixture was heated under reflux for 5 hours. Methanol was distilled off under reduced pressure, and dilute hydrochloric acid was added to the remaining aqueous soluiton to lower its pH down to about 5. The solid which separated out was collected by filtration, washed with water, and recrystallized from methanol, affording 2.3 g of 6-[p-[5-(1-imidazolyl)pentyloxy]phenoxy]-2,2-dimethylhexanoic acid.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 5 hours
3. distillationMethanol was distilled off under reduced pressure, and dilute hydrochloric acid
4. additionwas added to the remaining aqueous soluiton
5. customThe solid which separated out
6. filtrationwas collected by filtration
7. washwashed with water
8. customrecrystallized from methanol