1-[2-(Benzyloxycarbonylamino)-3-hydroxypropionyl]-4-(3-phenylpropyl)piperazine → 1-(2-Amino-3-hydroxypropionyl)-4-(3-phenylpropyl)piperazine

Participants

Reaction Steps

10% Palladium-on-carbon (100 mg) was added to a solution of 1.12 g of 1-[2-(benzyloxycarbonylamino)-3-hydroxypropionyl]-4-(3-phenylpropyl)piperazine in 30 ml of ethanol, and the mixture was stirred under a hydrogen gas stream until cessation of hydrogen absorption. The catalyst was then filtered off, and the filtrate was concentrated under reduced pressure to give 800 mg of 1-(2-amino-3-hydroxypropionyl)-4-(3-phenylpropyl)piperazine.

Provenance & Evidence