4-Methylmorpholine → HCID 14881553, compound

Participants

Reaction Steps

To a solution of 1.3 g of N-formyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid in 50 ml of tetrahydrofuran plus 10 ml of N,N-dimethylformamide, there were added, at 4° C. or below, 1.16 g of L-methionine methyl ester hydrochloride, 1.17 g of 1-hydroxybenzotriazole, 560 mg of N-methylmorpholine and 1.32 g of dicyclohexylcarbodiimide, in that order. The mixture was stirred at 4° C. or below for 1 hour and then at room temperature for 1 hour. The reaction mixture was then treated in the same manner as in Example 1. Purification by silica gel column chromatography [eluent: chloroform-methanol (9:1)] gave 820 g of [N-formyl-2-(3-pyridyl)thiazolidine-4-carbonyl]-L-methionine methyl ester as an oil.

Provenance & Evidence