N-tert-butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid → [2-(3-pyridyl)thiazolidine-4-carbonyl]-D-methionine ethyl ester dihydrochloride

HRID 704424Notes

Reaction equation

HRID 704424 reaction equation
C(OC([N:8]1[CH:12]([C:13]([OH:15])=O)[CH2:11][S:10][CH:9]1[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C.[ClH:22].[CH2:23]([O:25][C:26](=[O:33])[C@@H:27]([CH2:29][CH2:30][S:31][CH3:32])[NH2:28])[CH3:24]>>[ClH:22].[ClH:22].[CH2:23]([O:25][C:26](=[O:33])[C@@H:27]([CH2:29][CH2:30][S:31][CH3:32])[NH:28][C:13]([CH:12]1[CH2:11][S:10][CH:9]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[NH:8]1)=[O:15])[CH3:24]

Participants

3

Reactant 2

HCID 14772789N-tert-butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acidHCID 44717125H-D-Met-oet hcl

Product 1

HCID 14881582[2-(3-pyridyl)thiazolidine-4-carbonyl]-D-methionine ethyl ester dihydrochloride

Procedure

N-tert-Butoxycarbonyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid and D-methionine ethyl ester hydrochloride were used as the starting materials and treated in the same manner as in Example 4 to give [2-(3-pyridyl)thiazolidine-4-carbonyl]-D-methionine ethyl ester dihydrochloride. Melting point 94°-96° C.

Workup

  1. additiontreated in the same manner as in Example 4

Sources & evidence

ORD record
ord-0b4f47fab21f4dd19ab4bca21642e5cc
Source dataset
uspto-grants-1991_01
Patent number
US04987132

Reaction notes

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